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Síndrome alfa-gal: Dois casos clínicos
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Abstract(s)
Introdução: Os casos descritos de alergia a carnes vermelhas têm vindo a aumentar e estão relacionados com a sensibilização à galactose -α -1,3 -galactose (alfa -gal). Casos clínicos: Os autores descrevem dois casos de alergia a carnes vermelhas por sensibilização a alfa -gal. Caso A: Sexo masculino, 47 anos, antecedentes de atopia, com vários episódios de urticária generalizada e angioedema do lábio entre 30 minutos a 6 horas após ingestão de carnes verme lhas. Os testes cutâneos foram positivos para carnes vermelhas e as IgE específicas positivas para carne de porco, vaca e alfa -gal. Caso B: Sexo masculino, 42 anos, sem antecedentes de atopia, com urticária generalizada e sensação de edema da orofaringe 6 horas após ingestão de carne de porco (> 10 episódios). Os testes cutâneos foram positivos para carne de porco e as IgE específicas positivas para carne de porco, vaca e alfa -gal. Após evicção de carnes verme lhas nenhum doente voltou a apresentar sintomas.
Background: Hypersensitivity to red meat has been increasing and is related to sensitization to galactose -α‑1,3‑galactose (alpha -gal). Case reports: The authors describe 2 cases of red meat allergy due to alpha -gal sensitization. Case A: 47 -year -old atopic male, with several episodes of generalized urticaria and lip angioedema, 30 minutes to 6 hours after ingestion of red meat. Skin tests were positive to red meat and specific IgE positive for pork, beef and alpha‑gal. Case B: 42 -year old male without any atopic disease, with generalized urticaria and oropharyngeal tightening 6h after pork ingestion (> 10 episodes). Skin tests were positive to pork and specific IgE assay positive for pork, beef and alpha‑gal. After red meat avoidance, no other manifestations were reported
Background: Hypersensitivity to red meat has been increasing and is related to sensitization to galactose -α‑1,3‑galactose (alpha -gal). Case reports: The authors describe 2 cases of red meat allergy due to alpha -gal sensitization. Case A: 47 -year -old atopic male, with several episodes of generalized urticaria and lip angioedema, 30 minutes to 6 hours after ingestion of red meat. Skin tests were positive to red meat and specific IgE positive for pork, beef and alpha‑gal. Case B: 42 -year old male without any atopic disease, with generalized urticaria and oropharyngeal tightening 6h after pork ingestion (> 10 episodes). Skin tests were positive to pork and specific IgE assay positive for pork, beef and alpha‑gal. After red meat avoidance, no other manifestations were reported
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Keywords
Alergia alimentar alfa-gal carnes vermelhas Madeira Island Região Autónoma da Madeira allergy
Citation
Rev Port Imunoalergologia 2021; 29 (1): 49-53