Percorrer por autor "Carvalho, Fátima G."
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- Additive manufacturing (3D printing): a new approach for the manufacture of individualized medicinesPublication . Figueiredo, Sara; Brízio, Ana; Carvalho, Fátima G.; Fernandes, Ana I.; Pinto, João F.
- Effect of plasticizer content on the processability of paroxetine-loaded filaments by fused deposition modellingPublication . Figueiredo, Sara; Fernandes, Ana Isabel; Henriques Dias Fernandes, Ana Isabel; Carvalho, Fátima G.; Pinto, João F.Poster presented at the 14th PBP World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. Viena, Austria, 18-21 March 2024
- Estudo de caso : otimização do fabrico de medicamentos impressos na farmácia comunitáriaPublication . Figueiredo, Sara; Fernandes, A.I.; Carvalho, Fátima G.; Pinto, João F.
- Estudo de caso: otimização do fabrico de medicamentos impressos na Farmácia ComunitáriaPublication . Figueiredo, Sara; Fernandes, Ana Isabel; Carvalho, Fátima G.; Pinto, João F.Poster apresentado no Congresso Nacional dos Farmacêuticos 2024. Lisboa, 21-23 Novembro 2024
- Exploring environmental settings to improve the printability of paroxetine-loaded filaments by fused deposition modellingPublication . Figueiredo, Sara; Fernandes, Ana Isabel; Carvalho, Fátima G.; Pinto, João F.The successful integration of hot-melt extrusion (HME) and fused deposition modelling (FDM) depends on a better understanding of the impact of environmental conditions on the printability of formulations, since they significantly affect the properties of the raw materials, whose control is crucial to enable three-dimensional printing (3DP). Hence, the objective of this work was to investigate the correlation between the environmental settings and the properties of paroxetine (PRX)-loaded filaments, previously produced by HME, which affect printability by FDM. The influence of different drying methods of the physical mixtures (PMs) and HME-filaments (FILs) on the quality and printability of these products was also assessed. The printability of FILs was evaluated in terms of the water content, and the mechanical and thermal properties of the products. Stability studies and physicochemical, thermal, and in vitro dissolution tests were carried out on the 3D-printed tablets. Stability studies demonstrated the high ductility of the PRX loaded FILs, especially under high humidity conditions. Under low humidity storage conditions (11% RH), the FILs became stiffer and were successfully used to feed the FDM printer. Water removal was slow when carried out passively in a controlled atmosphere (desiccator) or accelerated by using active drying methods (heat or microwave). Pre-drying of the PRX/excipients and/or PMs did not show any positive effect on the printability of the FIL. On the contrary, dry heat and, preferably, microwave mediated drying processes were shown to reduce the holding time required for successful FDM printing, enabling on-demand production at the point of care.
- Impact of formulation of drug containing blends on 3D printing by fused deposition modellingPublication . Fernandes, A.I.; Figueiredo, Sara; Carvalho, Fátima G.; Pinto, João F.
- Performance and paroxetine stability in tablets manufactured by fused deposition modelling-based 3D printingPublication . Figueiredo, Sara; Fernandes, A.I.; Carvalho, Fátima G.; Pinto, João F.Objectives: The objective of this study was to develop a method for the preparation and characterization of paroxetine (PRX) tablets, obtained by coupling hot-melt extrusion and fused deposition modelling (FDM)-based three-dimensional printing (3DP) technology. The impact of the printing process parameters on the drug stability and on the tablets performance was assessed.
- Performance and paroxetine stability in tablets manufactured by fused deposition modelling-based 3D printingPublication . Figueiredo, Sara; Fernandes, Ana I.; Carvalho, Fátima G.; Pinto, João F."Objectives: The objective of this study was to develop a method for the preparation and characterization of paroxetine (PRX) tablets, obtained by coupling hot-melt extrusion and fused deposition modelling (FDM)-based three-dimensional printing (3DP) technology. The impact of the printing process parameters on the drug stability and on the tablets performance was assessed.
- Preparation of medicines by three dimensional printing and personalization of therapy in compounding pharmacies : a case studyPublication . Figueiredo, Sara; Fernandes, A.I.; Cardoso, Nuno; Carvalho, Fátima G.; Pinto, João F.
- Selection of hydroxypropylcellulose grade for paroxetine 3D printable formulations for fused deposition modellingPublication . Figueiredo, Sara; Pinto, João F.; Carvalho, Fátima G.; Fernandes, A.I.