Lourenço, TâniaReis, Ana Catarina Rodrigues da SilvaAlvarez, Enrique Jesús SáezAbreu-Figueiredo, R.Charepe, ZaidaMarques, GoretiVieira Gonçalves, Maria2022-06-272022-06-272022-03http://hdl.handle.net/10400.26/41200Introduction: Lockdowns due to the COVID-19 pandemic radically changed nursing education. Along with social isolation, the transition to distance education affected the well-being of students in several countries, particularly Portugal and Spain. Objectives: To identify which variables are predictors of psychological well-being for Portuguese and Spanish nursing students during mandatory lockdowns. Methods: A multicenter, cross-sectional, descriptive, correlational study involving a sample of 1075 students (944 women, mean age 22.46+/−4.95 years). Data were collected from an online questionnaire which applied the following scales: Perceived Stress Scale (α =.820); Brief COPE-14 Subscales (α =.430 < 0.930); Well-being Manifestations Measure Scale (α =.940); Herth Hope Index (α=.850). A multiple regression model was created to predict the psychological well-being of nursing students. Results: The following predictor variables were identified in the model of the psychological well-being of students during the COVID-19 pandemic: perceived stress (β=.405; p≤.001); hope (β=.404; p≤.001); and the mechanisms of active coping (β=.405; p≤.001), planning (β=.097; p≤.001), and positive reinterpretation (β=.053; p = .12). These five variables predicted 62.0% of the nursing students’ psychological well-being (R2=.620; F = 350.82; p≤.001). Conclusion: Promoting students’ mental health is essential, especially in periods of great adversity, such as a pandemic. Our results lead the way for the design and validation of an intervention program that addresses the five variables identified as predictors of students’ psychological well-beingporPsychological adaptationHopeStressNursing studentsCOVID-19journal article10.1177/23779608221094547