Ribeiro, A.Freitas, C.Matos, L.Gouveia, A.Gomes, F.Silva Carvalho, J. L.Almeida, H.2020-07-282020-07-282017Ribeiro, A., Freitas, C., Matos, L. et al. Age-related expression f TGF beta family receptors in human cumulus oophorus cells. J Assist Reprod Genet 34, 1121–1129 (2017).1058-0468 (Print) 1573-7330 (Online)http://hdl.handle.net/10400.26/33005During ovarian follicle growth, local cellular interactions are essential for oocyte quality acquisition and successful fertilization. While cumulus cells (CCs) nurture oocytes, they also deliver oocyte-secreted factors (OSFs) that activate receptors on CCs. We hypothesized that disturbance of those interactions contributes to age-related lower reproductive success in women submitted to assisted reproductive technology treatments.engAdultAnaplastic Lymphoma KinaseBone Morphogenetic Protein Receptors, Type IBone Morphogenetic Protein Receptors, Type IICumulus CellsFemaleFertilization in VitroGene Expression Regulation, DevelopmentalHumansMiddle AgedOocytesOvarian FollicleProtein-Serine-Threonine KinasesReceptor Protein-Tyrosine KinasesReceptor, Transforming Growth Factor-beta Type IReceptors, Transforming Growth Factor betaReproductive Techniques, AssistedPortugaljournal article10.1007/s10815-017-0930-6