Póvoa, RicardoCanelas, AntónioMartins, RicardoLourenço, NunoHorta, NunoGoes, João2025-05-082025-05-082020-03Póvoa, R., Canelas, A., Martins, R., Horta, N., Lourenço, N., & Goes, J. (2020). A new family of CMOS inverter-based OTAs for biomedical and healthcare applications. Integration, 71, 38-480167-9260http://hdl.handle.net/10400.26/57785This paper presents a new family of innovative operational transconductance amplifier (OTA) topologies based on CMOS inverter structures, with improved gain and energy-efficiency. This new family of OTA designs is suitable for biomedical and healthcare circuits and systems, due to the high energy-efficiency, improved gain and low level of noise contribution, when compared to the state-of-the-art in this field. In this paper, two fully-differential implementations are presented, a first one with a double CMOS branch biased by two pairs of voltage-combiners structures in both NMOS and PMOS configurations, and a second one with folded voltage-combiners specifically targeting low voltage applications, e.g., supplies below 1 V. The usage of voltage-combiners to bias the OTAs improves the gain and the gain-bandwidth product, therefore improving the energy-efficiency figure-of-merit. High values of figure-of-merit are achieved in both implementations, i.e., more than 1600 MHz × pF/mA and 2000 MHz × pF/mA, gain values above 53 dB and 50 dB under supply sources of 2 V and 0.7 V respectively. The folded voltage-combiners biased OTA is able to operate correctly under a voltage supply down to 0.7 V with proper DC biasing. The results are finally compared with state-of-the-art in this field and the potential of the circuits is fulfilled using a state-of-the-art layout-aware integrated-circuit optimization framework, AIDA, particularly relevant in order to overcome the device stacking problematic for lower voltages.engCMOSInverter-basedLow-powerLow-voltageEnergy-efficiencyOTAAmplifiersTelescopicFoldedVoltage-combinersBiomedicalHealthcarejournal article10.1016/j.vlsi.2019.12.004