Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

Rocha, CheilaDuarte, JoanaBorrego, PedroCalado, RitaMarcelino, José MariaTendeiro, RitaValadas, EmíliaSousa, Ana EspadaTaveira, Nuno2019-12-122019-12-122017-11AIDS: November 13, 2017 - Volume 31 - Issue 17 - p 2431–2433. doi: 10.1097/QAD.00000000000016610269-93701473-5571http://hdl.handle.net/10400.26/30469Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.engHIV-2 antibodiesMemory B cellsPotency of HIV-2-specific antibodies increase in direct association with loss of memory B cellsjournal article10.1097/QAD.0000000000001661