Ribeiro, Sandrado Sameiro Faria, MariaMascarenhas-Melo, FilipaFreitas, IsabelMendonca, Maria IsabelNascimento, HenriqueRocha-Pereira, PetronilaMiranda, VascoMendonça, DenisaQuintanilha, AlexandreBelo, LuísCosta, ElísioReis, FlávioSantos-Silva, Alice2021-02-152021-02-152012Am J Nephrol 2012;36:317–323http://hdl.handle.net/10400.26/35487Cardiovascular diseases are the major cause of morbidity and mortality in hemodialysis (HD) patients. These patients present reduced paraoxonase 1 (PON1) activity that depends on genetic and non-genetic factors; however, how these factors influence PON1 activity in HD patients is poorly clarified. Our aim was to evaluate the influence of two polymorphisms and non-genetic factors on PON1 activity in HD patients.engAdiponectinAgedAged, 80 and overAnemiaAryldialkylphosphataseBiomarkersC-Reactive ProteinEnzyme ActivationErythropoietinFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInflammationInterleukin-6Kidney Failure, ChronicLipidsMaleMiddle AgedPolymorphism, GeneticPrognosisRisk FactorsRenal DialysisMadeira IslandPortugaljournal article10.1159/000342235