Cunha-Santos, CatarinaFigueira, Tiago N.Borrego, PedroOliveira, Soraia S.Rocha, CheilaCouto, AndreiaCantante, CátiaSantos- Costa, QuirinaAzevedo-Pereira, José M.Fontes, Carlos M. G. A.Taveira, NunoAires-Da-Silva, FredericoCastanho, Miguel A. R. B.Veiga, Ana SaloméGonçalves, João2016-10-122017-08-012016-07AIDS. 2016 Jul 17;30(11):1691-701. doi: 10.1097/QAD.0000000000001108.1691-1701http://hdl.handle.net/10400.26/15096This is a non-final version of an article published in final form in AIDS. 2016 Jul 17;30(11):1691-701."Objective: To develop a novel and potent fusion inhibitor of HIV infection based on a rational strategy for synthetic antibody library construction. Design: The reduced molecular weight of single-domain antibodies (sdAbs) allows targeting of cryptic epitopes, the most conserved and critical ones in the context of HIV entry. Heavy-chain sdAbs from camelids are particularly suited for this type of epitope recognition because of the presence of long and flexible antigen-binding regions [complementary-determining regions (CDRs)]."engHIV fusion inhibitorHR1Single-domain antibodySynthetic libraryVariable light-chainjournal article0.1097/QAD.0000000000001108