Entry inhibitors and Carbosilane dendrimers are potent inhibitors of cell-associated HIV-2 infection

Diniz, A. R.Briz, V.Borrego, P.Palladino, C.Rodés, C.De la Mata, F. J.Gómez, R.Muñoz-Fernández, M. A.Taveira, N.2016-10-122016-10-122015-03-22http://hdl.handle.net/10400.26/15088Poster presented at the 2015 Keystone Symposia Conference X5: HIV Vaccines. Banff, Alberta, Canada, 22-27 March 2015"Pre-exposure prophylaxis with topical microbicides formulated with antiviral agents can prevent HIV-1 acquisition. The ideal microbicide should prevent both cell-free and cell-associated HIV-1 and HIV-2 infections in the vaginal or rectum mucosa. So far, few candidate microbicides have been tested against HIV-2. Previously, we have shown that anionic carbosilane dendrimers 2G-S16 (sulphonate), G2-NF16 (naphthylsulfonated) and G3-S16 (sulphated-end groups) have potent antiviral activity against HIV-1. In this work, we evaluated the activity of these dendrimers and the fusion inhibitors T-1249 and T20 in preventing cell-free and cellassociated HIV-2 infection."engHIV-2 infectionEntry inhibitorsCarbosilane dendrimersEntry inhibitors and Carbosilane dendrimers are potent inhibitors of cell-associated HIV-2 infectionconference object