Schneider, Carolin V.Hamesch, KarimGross, AnnikaMandorfer, MattiasMoeller, Linda S.Pereira, VitorPons, MonicaKuca, PawelReichert, Matthias C.Benini, FedericaBurbaum, BarbaraVoss, JessicaGutberlet, MarlaWoditsch, VivienLindhauer, CeciliaFromme, MalinKümpers, JuliaBewersdorf, LisaSchaefer, BenediktEslam, MohammedBals, RobertJanciauskiene, SabinaCarvão, JoanaNeureiter, DanielZhou, BiaohuanWöran, KatharinaBantel, HeikeGeier, AndreasDirrichs, TimmStickel, FelixTeumer, AlexanderVerbeek, JefNevens, FrederikGovaere, OlivierKrawczyk, MarcinRoskams, TaniaHaybaeck, JohannesLurje, GeorgChorostowska-Wynimko, JoannaGenesca, JoanReiberger, ThomasLammert, FrankKrag, AleksanderGeorge, JacobAnstee, Quentin M.Trauner, MichaelDatz, ChristianGaisa, Nadine T.Denk, HelmutTrautwein, ChristianAigner, ElmarStrnad, Pavel2020-12-072020-12-072020Liver Phenotypes of European Adults Heterozygous or Homozygous for Pi* Z Variant of AAT (Pi* MZ vs Pi* ZZ genotype) and Non-carriers0016-5086http://hdl.handle.net/10400.26/34284Homozygosity for the Pi∗Z variant of the gene that encodes the alpha-1 antitrypsin peptide (AAT), called the Pi∗ZZ genotype, causes a liver and lung disease called alpha-1 antitrypsin deficiency. Heterozygosity (the Pi∗MZ genotype) is a risk factor for cirrhosis in individuals with liver disease. Up to 4% of Europeans have the Pi∗MZ genotype; we compared features of adults with and without Pi∗MZ genotype among persons without preexisting liver disease.engjournal article10.1053/j.gastro.2020.04.058