Aguiar, LauraSemente, IldegárioFerreira, JoanaCarvalho, AndreiaSilva, Alda P.Caroça, CristinaCaria, HelenaDamasceno, AlbertinoLaires, Maria J.Sardinha, LuísMonteiro, CristinaMascarenhas, Mário R.Faustino, PaulaInácio, ÂngelaBicho, Manuel2024-02-152024-02-152021Aguiar, L., Semente, I., Ferreira, J., Carvalho, A., Silva, A. P., Caroça, C., Caria, H., Damasceno, A., Laires, M. J., Sardinha, L., Monteiro, C., Mascarenhas, M. R., Faustino, P., Inácio, Â., & Bicho, M. (2021). Differences in the genotype frequencies of genes related to blood pressure regulation - a comparative study between South-West Europe and Peri-equatorial Africa. African health sciences, 21(4), 1669–1676.1729-0503http://hdl.handle.net/10400.26/49847Background: Since the emergence of the genus Homo, hominids have occupied a wide variety of environments, facing different selective pressures. Objectives: The aim this study is to compare genotype frequencies between South-West Europe and Peri-equatorial Africa in genes potentially modulators of blood pressure. Methods: The analyzed sample consisted of 325 individuals from Portugal and 226 individuals from Africa (48 from Mo- zambique and 178 from São Tomé and Príncipe). The following genetic variants were analyzed: intron 4 VNTR in eNOS, rs1050829 in G6PD, -3.7kb α-thalassemic deletion in HBA, rs1800457 in CYB5R3, Hp 1/2 genotype/phenotype in Hp and intron 16 I/D in ACE. Results: Frequencies of genotypes with the 4a allele in eNOS (p<0.001), the G allele in G6PD (p<0.001), the α-3.7 kb in HBA (p <0.001), the C allele in the CYB5R3 (p<0.001) were higher in Peri-equatorial Africa. The Hp 1.1 genotype of Hp has a higher frequency in Peri-equatorial Africa (p=0.002). ACE shows no significant differences. Conclusion: Results show differences in five genetic variants. Conditions of extreme heat and humidity, characteristic of Peri-equatorial Africa, have been associated with increased sodium loss. This study suggests that selected compensatory mechanisms printed in the genome, are nowadays risk factors for hypertension in Peri-equatorial Africa.engBlood pressureGeneticsAfricajournal article10.4314/ahs.v21i4.21