Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.26/9562
Título: Noise-induced gastric lesions : a light and electron microscopy study of the rat gastric wall exposed to low frequency noise
Autor: Fonseca, Jorge
Martins-dos-Santos, José
Oliveira, Pedro
Laranjeira, Nuno
Águas, Artur
Castelo-Branco, Nuno
Palavras-chave: Gastric mucosa
Noise effects
Microscopy, electron
Data: Jan-2012
Citação: Fonseca J, Martins-dos-Santos J, Oliveira P, Laranjeira N, Aguas A, Castelo-Branco N. Noise-induced gastric lesions: a light and electron microscopy study of the rat gastric wall exposed to low frequency noise. Arq Gastroenterol. 2012 Jan-Mar;49(1):82-8
Resumo: "Context - Only a few studies evaluated the digestive alterations caused by low frequency noise (LFN) and most focused only on mucosal alterations. Objectives - To investigate the morphological injury of LFN-exposed gastric wall, beyond the epithelial layer. Methods - Wistar rats were exposed to low frequency noise (LFN), during increasing periods, 1 to 13 weeks. A control group was kept in silence. Gastric specimens were studied using: (i) light microscopy with hematoxylin-eosin and immunostaining for collagens; (ii) transmission electron microscopy; (iii) morphometry allowing statistical analysis. Results - Submucosa of all LFN-exposed animals exhibit increased thickness with fibrous proliferation. Transmission electron microscopy showed massive collagen deposition. Immunostaining identified collagen IV as responsible for the increased thickness. Morphometry allowed the demonstration of a significant difference of thickness between control and exposed groups. Vascular alterations included: i) intima proliferation and thickening, rupture of the internal elastic lamina, thrombotic changes; ii) thickening of the media; iii) after 9 weeks of LFN-exposure, we found new formed vessel presenting tortuous and twisted. There is a significant difference of arterial wall thickness between control and exposed groups. Conclusions - Deeper layers of gastric wall undergo alterations, including fibrosis of the submucosa caused by collagen IV deposition, an early marker of neoangiogenesis. Vascular alterations included thickening and thrombotic phenomena, but also images of newly formed vessels. This study suggests that, at least in the stomach, LFN-induced fibrosis could be linked with neoangiogenesis."
Peer review: yes
URI: http://hdl.handle.net/10400.26/9562
DOI: 10.1590/S0004-28032012000100014
ISSN: 0004-2803
Versão do Editor: http://dx.doi.org/10.1590/S0004-28032012000100014
Aparece nas colecções:EM - Artigos Científicos

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