Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.26/14327
Título: A randomized trial of nebulized 3% hypertonic saline with salbutamol in the treatment of acute bronchiolitis in hospitalized infants
Autor: Flores, P
Mendes, AL
Neto, AS
Palavras-chave: Bronquiolite Viral
Nebulizadores e Vaporizadores
Solução Salina Hipertónica
Bronchodilator Agents
Nebulizers and Vaporizers
Saline Solution, Hypertonic
Bronchiolitis, Viral
Data: Abr-2016
Citação: Pediatr Pulmonol. 2016 Apr;51(4):418-25.
Resumo: OBJECTIVE: Acute bronchiolitis is a common disorder of infants that often results in hospitalization. Apart from supportive care, no therapy has been shown to influence the course of the disease, except for a possible effect of nebulized hypertonic saline (HS). To determine whether this does have beneficial effects on length of stay in hospital or on severity scores, we undertook a double-blind, randomized, controlled trial in a pediatric department of a Portuguese hospital. METHODS: Previously healthy infants, younger than 12 months, hospitalized with mild-to-moderate acute viral bronchiolitis were randomized to receive either nebulized 3% (hypertonic, HS) or 0.9% (normal, NS) saline during their entire hospital stay. Primary endpoints were: length of hospital stay and severity scores on each day of hospitalization. Need for supplemental oxygen, further add-on medications and adverse effects were also analyzed. RESULTS: Sixty-eight patients completed the study (HS: 33; NS: 35). The median length of hospital stay did not differ between groups: HS: 5.6 ± 2.3 days; NS: 5.4 ± 2.1 days (P = 0.747). We found no difference between groups in severity scores from day 1 to day 4. There were no differences in need for supplemental oxygen or add-on medications. Patients in HS group had significantly more cough (46% vs. 20%, P = 0.025) and rhinorrhoe (58% vs. 31%, P = 0.30). CONCLUSION: This study does not support the use of nebulized HS over NS in therapy of hospitalized children with mild-to-moderate acute viral bronchiolitis
Peer review: yes
URI: http://hdl.handle.net/10400.26/14327
DOI: 10.1002/ppul.23306
Aparece nas colecções:Saúde - CUF - Descobertas - Artigos Científicos

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