Percorrer por autor "Pereira, Joana"
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- Adverse outcome pathways associated with the ingestion of titanium dioxide nanoparticles : a systematic reviewPublication . Rolo, Dora; Assunção, Ricardo; Ventura, Célia; Alvito, Paula; Gonçalves, Lídia; Martins, Carla; Bettencourt, Ana; Jordan, Peter; Vital, Nádia; Pereira, Joana; Pinto, Fátima; Matos, Paulo; Silva, Maria João; Louro, HenriquetaTitanium dioxide nanoparticles (TiO2-NPs) are widely used, and humans are exposed through food (E171), cosmetics (e.g., toothpaste), and pharmaceuticals. The oral and gastrointestinal (GIT) tract are the first contact sites, but it may be systemically distributed. However, a robust adverse outcome pathway (AOP) has not been developed upon GIT exposure to TiO2-NPs. The aim of this review was to provide an integrative analysis of the published data on cellular and molecular mechanisms triggered after the ingestion of TiO2-NPs, proposing plausible AOPs that may drive policy decisions. A systematic review according to Prisma Methodology was performed in three databases of peer-reviewed literature: Pubmed, Scopus, and Web of Science. A total of 787 records were identified, screened in title/abstract, being 185 used for data extraction. The main endpoints identified were oxidative stress, cytotoxicity/apoptosis/cell death, inflammation, cellular and systemic uptake, genotoxicity, and carcinogenicity. From the results, AOPs were proposed where colorectal cancer, liver injury, reproductive toxicity, cardiac and kidney damage, as well as hematological effects stand out as possible adverse outcomes. The recent transgenerational studies also point to concerns with regard to population effects. Overall, the findings further support a limitation of the use of TiO2-NPs in food, announced by the European Food Safety Authority (EFSA).
- Caracterização dos pais e perceção dos mesmos sobre aulas de natação para bebésPublication . Encarnação, Ana; Mendes, Patrícia; Miranda, Sílvia; Gouveia, Carina; Pereira, Joana; Marques, Liliana; Nunes, Paulo; Figueiredo, Teresa; Figueira, Ana; Pereira, A; Ferreira, Cátia; Espada, MárioO objetivo do presente estudo foi aferir o perfil dos pais e perceção destes relativamente às aulas de natação para bebés. Quarenta e cinco pais de crianças integradas em aulas de natação para bebés em três piscinas do Distrito de Setúbal preencheram oquestionário. 82.2% dos educadores transmitiram ter mantido o hábito de prática desportiva no passado, ao passo que apenas 51.5% indicou manter a prática no momento do estudo. A totalidade dos pais considerou relevante a emissão de feedbackpor parte dos professores de natação para bebés nas aulas e o conhecimento das metodologias aplicadas nas aulas. É fundamental caracterizar os responsáveis pelo envolvimento de bebés em aulas de natação e compreender as suas ideias sobre a natação para bebés no sentido de procurar ser adaptada a oferta à procura da atividade em amplo crescimento.
- O Ciberespaço e a mutação da realidade: o caso dos EUAPublication . Pereira, Joana
- A classificação da Universidade, Alta e Sofia como património mundial da Unesco : uma reflexão sobre a divulgação de um destino turístico classificadoPublication . Pereira, Joana; Moura, AndreiaA grandeza e notoriedade da Universidade de Coimbra, bem como a classificação atribuída pela UNESCO, que a coloca junto do Património da Humanidade veio reforçar a sua importância e o seu interesse em termos de estudo científico no âmbito do turismo. Desta forma, verificou-se pertinente compreender o potencial trazido pela classificação UNESCO para o destino turístico de Coimbra e perceber de que forma as entidades turísticas locais assimilaram esta nova realidade em termos de divulgação do destino. Assim, em termos metodológicos procedeu-se à realização de um estudo exploratório de natureza qualitativa, através da realização de entrevistas às entidades turísticas locais, devidamente selecionadas de acordo com a sua pertinência e relação com a temática em estudo. Os resultados dão conta que a imagem do destino turístico de Coimbra é indissociável da própria Universidade e que o número de turistas aumentou após a sua classificação como património da Humanidade, apurando-se que a divulgação deste património e da sua chancela não é, de todo, eficiente.
- Comparação entre composição corporal e aptidão física em ginastas femininas de trampolins e acrobáticaPublication . Pereira, Joana; Vasques, Ana; Marques, Liliana; Nunes, Paulo; Pereira, A; Espada, Mário; Figueiredo, Teresa
- Development of green approaches for preconcentration of local anesthetics in biological matricesPublication . Pereira, Joana; Rocha, Daniela C.; Neng, Nuno R.; Torres, M. Edite; Quintas, Alexandre; Ahmad, Samir M.Poster presented at the CQE Days - 5º encontro anual do Centro de Química Estrutural do Instituto Superior Técnico da Universidade de Lisboa. Lisboa, 25-26 may 2023
- Development of green methodologies for pre-concentration of local anaesthetics in biological matricesPublication . Pereira, Joana; Rocha, Daniela C.; Neng, Nuno R.; Torres, M. Edite; Quintas, Alexandre; Ahmad, Samir M.Poster presented at the 6th International Congress of CiiEM—Immediate and Future Challenges to Foster One Health. Monte de Caparica, 5-7 july 2023
- Is there a C-reactive protein value beyond which one should consider infection as the cause of acute heart failure?Publication . Pereira, Joana; Ribeiro, Ana; Ferreira-Coimbra, Joao; Barroso, Isaac; Guimaraes, Joao-Tiago; Bettencourt, Paulo; Lourenco, PatriciaBACKGROUND: Heart Failure (HF) is a low grade inflammatory condition. High sensitivity C-reactive protein (hsCRP) is an established marker of inflammation. A cut-off value of hsCRP beyond which an infection should be sought has never been studied in HF. We aimed to determine the best hsCRP cut-off for infection prediction in acute HF. METHODS: We analyzed patients included in an acute HF registry - EDIFICA (Estratificação de Doentes com InsuFIciência Cardíaca Aguda). Admission hsCRP measurement was available as part of the registry's protocol. Patients with acute coronary syndrome as the cause of acute HF were excluded from the registry. Infection was considered according to the diagnosis registered in the discharge record. A receiver-operating characteristic (ROC) curve was used to determine the best hsCRP cut-off for infection prediction. RESULTS: We studied 615 patients. Mean age was 76 years, 45.2% were male, 60.3% had systolic dysfunction. Median admission hsCRP was 20.3 (9.5-55.5)mg/L; in 41.6% the cause of decompensation was an infection. The area under the ROC curve for admission hsCRP in the prediction of infection was 0.79 (0.76-0.83); the best hsCRP cut-off was 25 mg/L with a sensitivity of 72.7%, specificity 77.2%, positive predictive value 69.4% and negative predictive value 79.9%. Age and elevated hsCRP independently associated with an infection as the precipitant of acute HF. CONCLUSIONS: We suggest 25 mg/L as a cut-off beyond which an infection should be sought underlying acute HF. Almost 80% of the patients with hsCRP< 25 mg/L are not infected and 69.4% of those with higher hsCRP have a concomitant infection.
- Superior Mesenteric Artery Syndrome: A Rare Cause of Intestinal ObstructionPublication . Ribeiro, Andreia; Pereira, Joana; Tonel, Carla
- Trajetórias Relacionais e Reprodutivas Conducentes à Gravidez na Adolescência: a Realidade Nacional e Regional PortuguesaPublication . Pires, Raquel; Pereira, Joana; Pedrosa, Anabela Araújo; Bombas, Teresa; Vilar, Duarte; Vicente, Lisa; Canavarro, Maria CristinaIntroduction: The current study aimed to describe the relational and reproductive trajectories leading to adolescent pregnancy in Portugal, and to explore whether there were differences in this process according to adolescents’ place of residence. Material and Methods: Data were collected between 2008 and 2013 in 42 public health services using a self-report questionnaire developed by the researchers. The sample consisted of a nationally representative group of pregnant adolescents (n = 459). Results: Regardless of having had one (59.91%) or multiple sexual partners (40.09%), the majority of adolescents became pregnant in a romantic relationship, using contraception at the time of the conception and knowing the contraceptive failure which led to pregnancy (39.22%). In some regions other trajectories were highly prevalent, reflecting options such as planning the pregnancy (Alentejo Region/Azores Islands), not using contraception (Centro Region/Madeira Islands) or using it incorrectly, without identifying the contraceptive failure (Madeira Islands). On average, romantic relationships were longer than 19 months and adolescents’ partners were older than themselves (> 4 years) and no longer in school (75.16%); these results were particularly significant when the pregnancy was planned. Discussion: The knowledge gained in this study shows that prevention efforts must be targeted according to the adolescents’ needs in each region and should include high-risk male groups. Conclusion: Our results may enable more efficient health policies to prevent adolescent pregnancy in different country regions and support educators and health care providers on sexual education and family planning efforts.