Percorrer por autor "Agostinho, Joana Demmich Barbosa"
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- Design : optimization : introduction of disposables for biotech drug product processesPublication . Agostinho, Joana Demmich Barbosa; Mang, André; Ascenso, CarlaThe Quality-Time-Cost Iron triangle is in the middle of a pharmaceutical commercial production process. However, nowadays pharmaceutical companies try to optimize the security level of sterility assurance, available capacity and costs, looking for innovative technologies in order to improve their processes. Within this master thesis, the possibility to transfer active pharmaceutical ingredient solutions with a peristaltic pump and with overpressure in combination with a combined thawing and transfer disposable tube was tested. Moreover, the transfer speeds of three combined thawing and transfer disposable tubes in combination with the two transfer methods were measured in order to decide which combined disposable tube and which method is more suitable for the transfer of active pharmaceutical ingredient solutions and therefore, see if it is advantageous to replace the current single thawing and single transfer disposable tubes, taking also into account other additional factors. It is possible to transfer active pharmaceutical ingredient with a peristaltic pump and overpressure. However, the use of an optimized combined thawing and transfer disposable tube in combination with the overpressure transfer method would be an innovative process and would bring quality and efficiency to a pharmaceutical sterile drug product manufacturing process.