O Seu Saber Ocupa um Lugar! DSpace

Repositório Comum >
HB - Hospital de Braga >
HB - Endocrinologia >
HB - EDM - Artigos >

Please use this identifier to cite or link to this item: http://comum.rcaap.pt/handle/123456789/2514

Título: A marcoprolactinemia: da determinação laboratorial ao seu significado clínico
Outros títulos: Macroprolactinemia - laboratory determination and its clinical significance
Autor: Matos, C
Pereira, ML
Guimarães, JT
Palavras-chave: Macroprolactinemia
Issue Date: 2011
Citação: Acta Med Port. 2011;24 Suppl 4:929-38.
Resumo: Since prolactin (PRL) (a hormone produced by the anterior pituitary) was first identificated, the existence of hyperprolactinemic syndrome has been recognized. Main symptoms are galactorrhea, oligomenorrhea, amenorrhea and infertility in women and decreased libido and impotence in men. Macroprolactinemia reflects the predominance of circulating forms with reduced bioactivity not associated with typical clinical manifestations of hyperprolactinemia. It is identified by immunoassays commonly used in clinical practice, resulting in hyperprolactinemia. Polyetilenoglycol (PEG) is the most used method that removes PRL from serum. It is likely that the phenomenon of macroprolactinemia is consistently underestimated and unrecognized. Manufacturers of immunoassays for PRL have been slow to incorporate in the literature, validated protocols, and data related to the interference of PEG. From a clinical and biochemical point of view and, the main concern should be to avoid unnecessary investigation and treatment.
Arbitragem científica: yes
URI: http://comum.rcaap.pt/handle/123456789/2514
Appears in Collections:HB - EDM - Artigos

Files in This Item:

File Description SizeFormat
Macroprolactinemia.pdf334,17 kBAdobe PDFView/Open

Please give feedback about this item
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


© 2014 - REPOSITÓRIO COMUM - Comentários - Statistics
Promotores do RCAAP   Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência PO Sociedade do Conhecimento (POSC) Portal oficial da União Europeia