O Seu Saber Ocupa um Lugar! DSpace

Repositório Comum >
HB - Hospital de Braga >
HB - Patologia Clínica >
HB - PAT CLIN - Artigos >

Please use this identifier to cite or link to this item: http://comum.rcaap.pt/handle/123456789/2100

Título: Synovial sarcoma of nerve
Autor: Scheithauer, BW
Amrami, KK
Folpe, AL
Silva, AI
Edgar, MA
Woodruff, JM
Levi, AD
Spinner, RJ
Palavras-chave: Neoplasias do Sistema Nervoso Periférico
Sarcoma Sinovial
Issue Date: 2011
Editora: Elsevier
Citação: Hum Pathol. 2011;42(4):568-77.
Resumo: Tumors of peripheral nerve are largely neuroectodermal in nature and derived from 2 elements of nerve, Schwann or perineurial cells. In contrast, mesenchymal tumors affecting peripheral nerve are rare and are derived mainly from epineurial connective tissue. The spectrum of the latter is broad and includes lipoma, vascular neoplasms, hematopoietic tumors, and even meningioma. Of malignant peripheral nerve neoplasms, the vast majority are primary peripheral nerve sheath tumors. Malignancies of mesenchymal type are much less common. To date, only 12 cases of synovial sarcoma of nerve have been described. Whereas in the past, parallels were drawn between synovial sarcoma and malignant glandular schwannoma, an uncommon form of malignant peripheral nerve sheath tumor, molecular genetics have since clarified the distinction. Herein, we report 10 additional examples of molecularly confirmed synovial sarcoma, all arising within minor or major nerves. Affecting 7 female and 3 male patients, 4 tumors occurred in pediatric patients. Clinically and radiologically, most lesions were initially thought to be benign nerve sheath tumors. On reinterpretation of imaging, they were considered indeterminate in nature with some features suspicious for malignancy. Synovial sarcoma of nerve, albeit rare, seems to behave in a manner similar to its more common, soft tissue counterpart. Those affecting nerve have a variable prognosis. Definitive recommendations regarding surgery and adjuvant therapies await additional reports and long-term follow-up. The literature is reviewed and a meta-analysis is performed with respect to clinicopathologic features versus outcome.
Arbitragem científica: yes
URI: http://comum.rcaap.pt/handle/123456789/2100
Appears in Collections:HB - PAT CLIN - Artigos

Files in This Item:

File Description SizeFormat
Synovial sarcoma of nerve.pdf1,65 MBAdobe PDFView/Open
Statistics
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

© 2014 - REPOSITÓRIO COMUM - Comentários - Statistics
Promotores do RCAAP   Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência PO Sociedade do Conhecimento (POSC) Portal oficial da União Europeia