O Seu Saber Ocupa um Lugar! DSpace

Repositório Comum >
HB - Hospital de Braga >
HB - Anatomia Patológica >
HB - AN PAT - Artigos >

Please use this identifier to cite or link to this item: http://comum.rcaap.pt/handle/123456789/1828

Title: Analysis of EGFR overexpression, EGFR gene amplification and the EGFRvIII mutation in Portuguese high-grade gliomas
Authors: Viana-Pereira, M
Lopes, JM
Little, S
Milanezi, F
Basto, D
Pardal, F
Jones, C
Reis, RM
Keywords: Glioblastoma
Glioma
Neoplasias Cerebrais
Issue Date: 2008
Citation: Anticancer Res. 2008;28(2A):913-20.
Abstract: BACKGROUND: Patients with malignant gliomas do not respond to any current therapy. Epidermal growth factor receptor (EGFR) controls several oncogenic processes, being frequently up-regulated in gliomas due to overexpression, gene amplification and gene mutation. EGFR inhibitors are being tried in gliomas, yet the molecular determinants of therapeutic response are unclear. MATERIALS AND METHODS: EGFR overexpression, EGFRvIII mutation and EGFR amplification were determined by immunohistochemistry and chromogenic in situ hybridization (CISH) in 27 primary glioblastomas (GBM), 24 anaplastic oligodendrogliomas (AO) and four anaplastic oligoastrocytomas (AOA). RESULTS: EGFR overexpression was associated with EGFR amplification, being found in 48% and 53% GBM, 33% and 40% AO and 75% and 67% AOA, respectively. EGFRvIII was found in 22% GBM, 8% AO and was absent in AOA. No association was observed between EGFR alterations and patient survival. CONCLUSION: We characterized, for the first time, EGFR molecular alterations in Portuguese patients with malignant glioma and identified a subpopulation of patients presenting putative biomarkers for EGFR-based therapies.
Peer Reviewed: yes
URI: http://comum.rcaap.pt/handle/123456789/1828
Appears in Collections:HB - AN PAT - Artigos

Files in This Item:

File Description SizeFormat
Anticancer Res.pdf902.03 kBAdobe PDFView/Open
Statistics
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Estamos no RCAAP Governo Português separator Ministério da Educação e Ciência   Fundação para a Ciência e a Tecnologia

Financiado por:

POS_C UE
© 2009 - REPOSITÓRIO COMUM - Comentários - Statistics