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Please use this identifier to cite or link to this item: http://comum.rcaap.pt/handle/123456789/1816

Título: Indeterminate cell histiocytosis in association with acute myeloid leukemia
Autor: Ventura, F
Pereira, T
Duarte, ML
Marques, H
Pardal, F
Brito, C
Palavras-chave: Histiocitose
Leucemia Mielóide Aguda
Issue Date: 2010
Editora: Hindawi
Citação: Dermatol Res Pract. 2010:569345
Resumo: Indeterminate cell histiocytosis (ICH) is a rare proliferative disorder, in which the predominant cells share morphologic and immunophenotypic features from both Langerhans and non-Langerhans cell histiocytosis. We describe a 62-year-old man presenting a 2-month history of firm nodular lesions on the upper lip. Histopathology, immunohistochemical, and ultrastructural analysis showed typical findings of ICH. The patient was treated with thalidomide and almost complete regression of the lesions was reached within 7 months. Nevertheless, one month after remission, he developed an acute myeloid leukemia of the subtype monocytic leukemia (M5). The patient's condition rapidly worsened and he died due to a respiratory failure four weeks later. We present this case because apart of being rare it joins the effectiveness of thalidomide and the association with an acute monocytic leukemia. A review of the literature is made.
Arbitragem científica: yes
URI: http://comum.rcaap.pt/handle/123456789/1816
Appears in Collections:HB - DER - Artigos
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