Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.26/9917
Título: Estimates of 2012/13 influenza vaccine effectiveness using the case test-negative control design with different influenza negative control groups
Autor: Nunes, Baltazar
Machado, Ausenda
Guiomar, Raquel
Pechirra, Pedro
Conde, Patrícia
Cristovão, Paula
Falcão, Isabel
Palavras-chave: Vacinação
Vacina da Gripe
Gripe
Data: 2014
Editora: Elsevier
Resumo: Background: In recent years several reports of influenza vaccine effectiveness (VE) have been made early for public health decision. The majority of these studies use the case test-negative control design (TND),which has been showed to provide, under certain conditions, unbiased estimates of influenza VE. Nevertheless, discussions have been taken on the best influenza negative control group to use. The presentstudy aims to contribute to the knowledge on this field by comparing influenza VE estimates using three test-negative controls: all influenza negative, non-influenza respiratory virus and pan-negative.Methods: Incident ILI patients were prospectively selected and swabbed by a sample of general practitioners. Cases were ILI patients tested positive for influenza and controls ILI patients tested negative forinfluenza. The influenza negative control group was divided into non-influenza virus control group andpan-negative control group. Data were collected on vaccination status and confounding factors. InfluenzaVE was estimated as one minus the odds ratio of been vaccinated in cases versus controls adjusted for confounding effect by logistic regression.Results: Confounder adjusted influenza VE against medically attended laboratory-confirmed influenza was 68.4% (95% CI: 20.7–87.4%) using all influenza negatives controls, 82.1% (95% CI: 47.6–93.9%) usingnon-influenza controls and 49.4% (95% CI: −44.7% to 82.3%) using pan-negative controls.Conclusions: Influenza VE estimates differed according to the influenza negative control group used.These results are in accordance with the expected under the hypothesis of differential viral interference between influenza vaccinated and unvaccinated individuals. Given the wide importance of TND study further studies should be conducted in order to clarify the observed differences.
Peer review: yes
URI: http://hdl.handle.net/10400.26/9917
DOI: doi:10.1016/j.vaccine.2014.06.053
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0264410X14008548
Aparece nas colecções:DGS - Artigos Científicos

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