Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.26/6945
Título: Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
Autor: Nunes, Raquel J.
Oliveira, Paula de
Lages, Ana
Becker, Jörg D.
Marcelino, Paulo
Barroso, Eduardo
Perdigoto, Rui
Kelly, Jeffery W.
Quintas, Alexandre
Santos, Susana C. R.
Palavras-chave: Angiogenesis
Endothelial Cell
Familial Amyloidotic Polyneuropathy
Gene Expression
Microarray
Transthyretin
Vascular Biology
Data: 1-Nov-2013
Editora: ASBMB
Citação: THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 44, pp. 31752–31760, November 1, 2013
Resumo: "Background: The biological effects of transthyretin proteins on vasculature remain unknown. Results: V30M transthyretin tetramer modulates endothelial global gene expression, down-regulating pro-angiogenic genes, inducing apoptosis and inhibiting migration. Conclusion: Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells. Significance: This work has critical implications in the prevention of early hepatic artery thrombosis in familial amyloidotic polyneuropathy patients after liver transplantation."
Descrição: "This research was originally published in The Journal of Biological Chemistry. Raquel J. Nunes, et al. Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells. Journal Name. 2013; 288:31752-31760. © the American Society for Biochemistry and Molecular Biology."
Peer review: yes
URI: http://hdl.handle.net/10400.26/6945
DOI: 10.1074/jbc.M113.469858
ISSN: 0021-9258
e-1083-351X
Versão do Editor: http://www.jbc.org/content/288/44/31752
Aparece nas colecções:EM - Artigos Científicos

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