Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.26/2107
Título: Ulcerative colitis in northern Portugal and Galicia in Spain
Autor: Barreiro-da-Costa, M
Magro, F
Carpio, D
Lago, P
Echarri, A
Cotter, J
Pereira, S
Gonçalves, R
Lorenzo, A
Carvalho, L
Castro, J
Barros, L
Dias, JA
Rodrigues, S
Portela, F
Dias, C
Costa-Pereira, A
Palavras-chave: Colite Ulcerosa
Espanha
Portugal
Data: 2010
Editora: Wiley
Citação: Inflamm Bowel Dis. 2010;16(7):1227-38
Resumo: BACKGROUND: Clinical and therapeutic patterns of ulcerative colitis (UC) are variable in different world regions. The purpose of this study was to examine two close independent southern European UC populations from 2 bordering countries and observe how demographic and clinical characteristics of patients can influence the severity of UC. METHODS: A cross-sectional study was conducted during a 15-month period (September 2005 to December 2006) based on data of 2 Web registries of UC patients. Patients were stratified according to the Montreal Classification and disease severity was defined by the type of treatment taken. RESULTS: A total of 1549 UC patients were included, 1008 (65%) from northern Portugal and 541 (35%) from Galicia (northwest Spain). A female predominance (57%) was observed in Portuguese patients (P < 0.001). The median age at diagnosis was 35 years and median years of disease was 7. The majority of patients (53%) were treated only with mesalamine, while 15% had taken immunosuppressant drugs, and 3% biologic treatment. Most patients in both groups were not at risk for aggressive therapy. Extensive colitis was a predictive risk factor for immunosuppression in northern Portugal and Galicia (odds ratio [OR] 2.737, 95% confidence interval [CI]: 1.846-4.058; OR 5.799, 95% CI: 3.433-9.795, respectively) and biologic treatment in Galicia (OR 6.329, 95% CI: 2.641-15.166). Younger patients presented a severe course at onset with more frequent use of immunosuppressors in both countries. CONCLUSIONS: In a large population of UC patients from two independent southern European countries, most patients did not require aggressive therapy, but extensive colitis was a clear risk factor for more severe disease
Peer review: yes
URI: http://hdl.handle.net/10400.26/2107
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