http://comum.rcaap.pt/handle/123456789/1935 Thu, 20 Jun 2013 08:37:48 GMT 2013-06-20T08:37:48Z http://comum.rcaap.pt/handle/123456789/3879 Title: Decisões clínicas na doença de Crohn Authors: Magro, F; Correia, L; Lago, P; Macedo, G; Peixe, P; Portela, F; Ferreira, A; Gonçalves, R; et al Abstract: Introduction: Crohn s disease is a chronic inflammatory disease from gastrointestinal tract. The increase in incidence and heterogeneity of this pathology, with different presentations and prognostics leads to a constant concern in developing and improving its classification and treatment. Objectives: To establish recommendations (based on level of evidence and recommendation grades) to 5 questions considered as the clinical challenges of the therapeutic approach in Crohn s disease. Methods: The methodology adopted by the working group DC2 (Desafios Clínicos na Doença de Crohn) was based on the selection of 5 questions, by voting, and establishing recommendations to each question proposed to each subgroup. Discussion and approval of reflexions and final recommendations was carried out in a consensus meeting. Conclusion: It has been possible to base conclusions about the questions under study on evidence, being recommended: 1) having Crohn s disease under 40 years old, structuring phenotype disease and anal disease are predictive factors of bad prognostic; 2) it is possible to consider suspension of biologics in patients with endoscopic remission and normal biomarkers; 3) patients with biochemical markers of disease activity (CRP and calprotectina) have more probability of relapse; 4) in failure of biologics it is essential to assure that treatment with the first drug was optimized: with infliximab it s demonstrated that either reduction of the administration range or increasing the dose allows to recover the response in the majority of patients; as for adalimumab, patients should change from bimonthly to weekly administrations; 5) in case of Crohn s disease with intestinal surgery, use of therapeutic to reduce postoperative recurrence is indicated, particularly immunosupressors and biologics. Sun, 01 Jan 2012 00:00:00 GMT http://comum.rcaap.pt/handle/123456789/3879 2012-01-01T00:00:00Z http://comum.rcaap.pt/handle/123456789/3878 Title: Colecistectomia Videolaparoscópica Transumbilical Single Site com Equipamento de Laparoscopia Convencional Authors: Rolanda, C Abstract: artigo intitulado Colecistectomia videolaparoscópica transumbilical (single site) com equipamento de laparoscopia convencional recentemente publicado por Alves Júnior e colaboradores mereceu-nos atenção e algumas considerações que gostaria de partilhar. Embora aborde uma temática tradicionalmente adstrita à Cirurgia Geral, vale a pena revisitar alguns conceitos e perceber o contexto actual da cirurgia minimamente invasiva (MIS), onde também temos lugar enquanto gastrenterologistas. Sat, 01 Jan 2011 00:00:00 GMT http://comum.rcaap.pt/handle/123456789/3878 2011-01-01T00:00:00Z http://comum.rcaap.pt/handle/123456789/3876 Title: Peutz-Jeghers syndrome: capsule endoscopy to stage disease Authors: Antunes, H; Nascimento, J; Peixoto, P Tue, 01 Jan 2013 00:00:00 GMT http://comum.rcaap.pt/handle/123456789/3876 2013-01-01T00:00:00Z http://comum.rcaap.pt/handle/123456789/3676 Title: Doença Inflamatória Intestinal Pediátrica cada vez mais comum Authors: Nascimento, J; Neiva, F; Antunes, H Sun, 01 Jan 2012 00:00:00 GMT http://comum.rcaap.pt/handle/123456789/3676 2012-01-01T00:00:00Z