http://comum.rcaap.pt/handle/123456789/1951 2013-05-20T02:40:55Z http://comum.rcaap.pt/handle/123456789/3689 Title: Brain diffusion-weighted and diffusion tensor imaging findings in an infant with biotinidase deficiency Authors: Soares-Fernandes, JP; Magalhães, Z; Rocha, JF; Barkovich, AJ 2009-01-01T00:00:00Z http://comum.rcaap.pt/handle/123456789/3688 Title: MR imaging for diagnostic evaluation of encephalopathy in the newborn. Authors: Shroff, MM; Soares-Fernandes, JP; Whyte, H; Raybaud, C Abstract: Magnetic resonance (MR) imaging is used with increasing frequency to evaluate the neonatal brain because it can provide important diagnostic and prognostic information that is needed for optimal treatment and appropriate counseling. Special care must be taken in preparing encephalopathic neonates for an MR study, transporting them from the intensive care unit, monitoring their vital signs, and optimizing MR sequences and protocols. Moreover, to accurately interpret the findings, specific knowledge is needed about the normal MR imaging appearances of the physiologic processes of myelination, cell migration, and sulcation, as well as patterns of injury, in the neonatal brain at various stages of gestational development. Hypoxic-ischemic injury, the most common cause of neonatal encephalopathy, has characteristic appearances that depend on the severity and duration of the insult as well as the stage of brain development. Diffusion-weighted MR imaging and MR spectroscopy depict abnormalities earlier than do conventional MR imaging sequences. However, diffusion-weighted imaging, if performed in the first 24 hours after the insult, might lead to underestimation of the extent of injury. When the MR findings are atypical, the differential diagnosis of neonatal encephalopathy also should include congenital and metabolic disorders and infectious diseases. Despite recent advances in the MR imaging-based characterization of these conditions, the clinical history must be borne in mind to achieve an accurate diagnosis. 2010-01-01T00:00:00Z http://comum.rcaap.pt/handle/123456789/3557 Title: Primary spinal glioblastoma: A case report and review of the literature Authors: Morais, N; Mascarenhas, L; Soares- Fernandes, JP; Silva, A; Magalhães, Z; Moreira da Costa, A Abstract: Primary spinal glioblastoma (GBM) is a rare disease, with an aggressive course and a poor prognosis. We report a case of a 19-year-old male with a 4-week history of progressive weakness in both lower limbs, which progressed to paraparesis with a left predominance and difficulty in initiating urination over a week. Spine magnetic resonance imaging (MRI) showed an intramedullary expansile mass localised between T6 and T11. We performed a laminotomy and laminoplasty between T6 and T11 and the tumour was partially removed. Histopathological study was compatible with GBM. The patient was administered focal spine radiotherapy with chemotherapy with temozolamide. Serial MRI performed after the initial surgery demonstrated enlargement of the enhancing mass from T3 to T12 and subarachnoid metastatic deposits in C2 and C4, the pituitary stalk, interpeduncular cistern, left superior cerebellar peduncle and hydrocephalus. We review the literature with regard to the disease and treatment options, and report the unique features of this case. Primary spinal GBM is an extremely rare entity with a poor prognosis and a short survival time. An aggressive management of the different complications as they arise and improvement of current modes of treatment and new treatment options are required to improve survival and ensure better quality of life. 2013-01-01T00:00:00Z http://comum.rcaap.pt/handle/123456789/3512 Title: A ressonância magnética nuclear da coluna vertebral Authors: Magalhães, Z 2010-01-01T00:00:00Z