http://comum.rcaap.pt/handle/123456789/1889 2013-06-15T19:18:52Z 2013-06-15T19:18:52Z Ribas, S Soares, V Koch, P http://comum.rcaap.pt/handle/123456789/3655 2013-06-05T01:25:07Z 2008-01-01T00:00:00Z

Title: Grupo de Biópsia Aspirativa com Agulha Fina: análise dos primeiros 500 casos Authors: Ribas, S; Soares, V; Koch, P Abstract: O Grupo de Biópsia Aspirativa com Agulha Fina está integrado na Unidade de Cabeça e Pescoço que pertence ao Departamento de Cirurgia do Hospital de S. Marcos. Este grupo foi constituído e iniciou a sua actividade em 2005 e é responsável pela realização de biópsias aspirativas de agulha fina, directas e ecoguiadas, de nódulos localizados na cabeça e pescoço. Este trabalho pretende analisar os primeiros 500 casos de biópsias aspirativas com agulha fina da glândula tiróide. The Group of Fine-needle Aspiration Biopsy is a part of the Unit for Head and Neck which belongs to the Department of Surgery of the Hospital of S. Marcos. This group was formed and started his activity in 2005 and is responsible for carrying out fine needle aspiration biopsies, direct and ultrasound-guided, of nodules found in the head and neck. This paper aims to examine the first 500 cases of fine-needle aspiration biopsies of the thyroid gland.

2008-01-01T00:00:00Z Ribas, S Campelos, S Lamelas, J Mesquita-Rodrigues, A http://comum.rcaap.pt/handle/123456789/3650 2013-06-05T01:24:06Z 2009-01-01T00:00:00Z

Title: Tumor de Krukenberg: A propósito de um caso clínico Authors: Ribas, S; Campelos, S; Lamelas, J; Mesquita-Rodrigues, A

2009-01-01T00:00:00Z Ribas, S Campelos, S Reis, M Vilaça, S Falcão, J http://comum.rcaap.pt/handle/123456789/3645 2013-06-05T01:24:17Z 2009-01-01T00:00:00Z

Title: Metástase Rara de Melanoma Maligno: A propósito de um caso clínico Authors: Ribas, S; Campelos, S; Reis, M; Vilaça, S; Falcão, J

2009-01-01T00:00:00Z Costa, BM Viana-Pereira, M Fernandes, R Costa, S Linhares, P Vaz, R Pinheiro, C Lima, J Soares, P Silva, A Pardal, F Amorim, J Nabiço, R Almeida, R Alegria, C Pires, MM Pinheiro, C Carvalho, E Oliveira, P Lopes, JM Reis, RM http://comum.rcaap.pt/handle/123456789/3590 2013-06-05T01:23:13Z 2011-01-01T00:00:00Z

Title: Impact of EGFR genetic variants on glioma risk and patient outcome Authors: Costa, BM; Viana-Pereira, M; Fernandes, R; Costa, S; Linhares, P; Vaz, R; Pinheiro, C; Lima, J; Soares, P; Silva, A; Pardal, F; Amorim, J; Nabiço, R; Almeida, R; Alegria, C; Pires, MM; Pinheiro, C; Carvalho, E; Oliveira, P; Lopes, JM; Reis, RM Abstract: BACKGROUND: The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. Three EGFR polymorphisms have been described as having a transcriptional regulatory function: two single-nucleotide polymorphisms in the essential promoter region, -216G/T and -191C/A, and a polymorphic (CA)(n) microsatellite sequence in intron 1. We aimed to elucidate the roles of these EGFR polymorphisms in glioma susceptibility and prognosis. METHODS: We conducted a case-control study with 196 patients with glioma and 168 cancer-free controls. Unconditional multivariate logistic regression models were used to calculate ORs and 95% confidence intervals. A Cox regression model was used to evaluate associations with patient survival. False-positive report probabilities were also assessed. RESULTS: None of the EGFR -216G/T variants was significantly associated with glioma risk. The -191C/A genotype was associated with higher risk for glioma when the (CA)(n) alleles were classified as short for ≤16 or ≤17 repeats. Independently of the (CA)(n) repeat cutoff point used, shorter (CA)(n) repeat variants were significantly associated with increased risk for glioma, particularly glioblastoma and oligodendroglioma. In all tested models with different (CA)(n) cutoff points, only -191C/A genotype was consistently associated with improved survival of patients with glioblastoma. CONCLUSIONS: Our findings implicate EGFR -191C/A and the (CA)(n) repeat polymorphisms as risk factors for gliomas, and suggest -191C/A as a prognostic marker in glioblastoma. IMPACT: Our data support a role of these EGFR polymorphisms in determining glioma susceptibility, with potential relevance for molecularly based stratification of patients with glioblastoma for individualized therapies

2011-01-01T00:00:00Z